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KMID : 0357119790010010035
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Korean Journal of Immunology
1979 Volume.1 No. 1 p.35 ~ p.43
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Immune Response to Sheep Red Blood Cells in Mice Bearing Tumor Induced by 3-Methylcholanthrene
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鄭憲鐸/Chung, Hun-Taeg
河大有/Ha, Tai-You
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Abstract
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This study was undertaken to evaluate the immunological capacity of the mice bearing tumor induced by 3-methylcholanthrene (3-MCA). The age matched normal mice were used as control.
Mouse skin tumor was elicited by topical application of 0.2m1 of a 0.4% aceton solution of 3-MCA on the shaved dorsal skin and concomitant intramuscular inoculation of 10g prostaglandin Fa. (PG F:a) three times a week for two months. The cell-mediated immune response was determined by measuring the footpad swelling reaction and the humoral immune response was determined by easuring the antibody formation to sheep red blood cells
(SRBC). In addition, 4 hour´s skin reaction to SRBC and rosette formation of spleen cells with SRBC were measured.
All of the immunological parameters used in this study were lower in the tumor-bearing mice than in the normal mice. Among the parameters, the footpad swelling reaction was most severely depressed in the tumor-bearing mice. The titers of hemagglutinin and hemolysin were slightly lowered and both titers of mercaptoethanol-resistant (IgG) antibody and mercaptoethanol-sensitive (IgM) antibody were decreased in the tumor-bearing mice. The spleen weights were strikingly increased in the tumor-bearing mice. However, the numbers of rosette forming spleen cells were slightly decreased in the tumor-bearing mice. The four hour´s skin reactions were also depressed in the tumor-bearing mice.
This study clearly indicates that malignant tnmor suppresses the immunological responses of host,
paricularly cell-mediated immune response.
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